The reaction of trimethylsilyl α-trimethylsilylperoxy esters with ketones and aldehydes. A simple, efficient synthesis of 1, 2, 4-trioxan-5-ones

CW Jefford, JC Rossier, GD Richardson

文献索引：Jefford, Charles W.; Rossier, Jean-Claude; Richardson, Geoffrey D. Journal of the Chemical Society, Chemical Communications, 1983 , # 19 p. 1064 - 1065

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被引用次数: 2

摘要

The title compounds readily react in the presence of a catalytic amount of trimethylsilyl tfifluoromethanesulphon- ate to give the corresponding 3,6-substituted 1,2,4-trioxan-5-ones in good yields. ... The 1,2,4-trioxane ring system (1) has assumed new import- ance since it constitutes the crucial structural element of the sesquiterpene arteannuinl or Qinghaosu (2) which is remark- able for its potent anti-malarial activity.2 Methods for syn- thesizing ...