文献索引：Dupre, Brian; Bui, Huong; Scott, Ian L.; Market, Robert V.; Keller, Karin M.; Beck, Pamela J.; Kogan, Timothy P. Bioorganic and Medicinal Chemistry Letters, 1996 , vol. 6, # 5 p. 569 - 572
A novel class of biphenyl-based compounds were investigated for their ability to inhibit sialyl Lewis X (sLex) dependent binding of HL-60 cells to E-and P-selectin fusion proteins. Compounds (2b) and (2h) demonstrated improved binding as compared to both the natural ligand sLex and a previously reported inhibitor TBC-265 (1, R= 3-CH2CO2H).
