前往化源商城

Synthesis and xanthine oxidase inhibitory activity of 7-methyl-2-(phenoxymethyl)-5H-[1, 3, 4] thiadiazolo [3, 2-a] pyrimidin-5-one derivatives

…, SA Khanum, JNNS Chandra, F Ayisha, S Balaji…

文献索引:Sathisha; Khanum, Shaukath A.; Chandra, J.N. Narendra Sharath; Ayisha; Balaji; Marathe, Gopal K.; Gopal, Shubha; Rangappa Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 1 p. 211 - 220

全文:HTML全文

被引用次数: 27

摘要

An elevated level of blood uric acid (hyperuricemia) is the underlying cause of gout. Xanthine oxidase is the key enzyme that catalyzes the oxidation of hypoxanthine to xanthine and then to uric acid. Allopurinol, a widely used xanthine oxidase inhibitor is the most commonly used drug to treat gout. However, a small but significant portion of the population suffers from adverse effects of allopurinol that includes gastrointestinal upset, skin rashes ...

 相关合成线路

~57%

~%

~%

~50%

~%

~%

~%

~78%

~72%

~%

~79%

~82%

~52%

~81%

~%

~%

~%

~%

~%

~71%

~69%

~%

~77%

~80%

~%

~%

~%

~%

~55%

~%

~%

~%

~71%

~77%

~69%

~70%

~%

~51%

~%

~%

~%

~68%

~80%

~72%

~69%

~%

~%

~76%

~%