Bioorganic & medicinal chemistry letters

Bernthsen synthesis, antimicrobial activities and cytotoxicity of acridine derivatives

MM Patel, MD Mali, SK Patel

文献索引：Patel, Mehul M.; Mali, Mimansha D.; Patel, Saurabh K. Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 21 p. 6324 - 6326

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被引用次数: 14

摘要

The condensation reaction of diphenylamine with 2-oxo-2H-(substituted chromen)-4-yl acetic acid in presence of anhydrous zinc chloride afford 4-(acridine-9-ylmethyl)-2H- (substituted chromen)-2-one. The synthesized compounds were characterized by spectral studies and elemental analysis and screened for their in vitro antibacterial activity against Staphylococcus aureus, Staphylococcus pyogenes (gram+ ve), Escherichia coli, ...