Synthesis of C3′ modified nucleosides for selective generation of the C3′-Deoxy-3′-thymidinyl radical: A proposed intermediate in LEE induced DNA damage

…, BAS Al-Oudat, AC Bryant-Friedrich

文献索引：Audat, Suaad A. S.; Trzasko Love, Cherylann; Al-Oudat, Buthina A. S.; Bryant-Friedrich, Amanda C. Journal of Organic Chemistry, 2012 , vol. 77, # 8 p. 3829 - 3837

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被引用次数: 10

摘要

DNA damage pathways induced by low-energy electrons (LEEs) are believed to involve the formation of 2-deoxyribose radicals. These radicals, formed at the C3′ and C5′ positions of nucleotides, are the result of cleavage of the C–O phosphodiester bond through transfer of LEEs to the phosphate group of DNA oligomers from the nucleobases. A considerable amount of information has been obtained to illuminate the identity of the unmodified ...