Novel 6-alkoxypurine 2', 3'-dideoxynucleosides as inhibitors of the cytopathic effect of the human immunodeficiency virus

…, MH St. Clair, LW Frick, T Spector…

文献索引：Burns; St. Clair; Frick; Spector; Averett; English; Holmes; Krenitsky; Koszalka Journal of Medicinal Chemistry, 1993 , vol. 36, # 3 p. 378 - 384

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被引用次数: 30

摘要

Twenty-one 6-alkoxypurine 2', 3'-dideoxynucleosides were enzymatically Synthesized with nucleoside phosphorylases purified from E. coli. Eighteen analogs exhibited anti-HIV-1 activity in MT4 cells. Two analogs, 6-(hexyloxy)-(17) and 64heptyloxy)-(18) purine 2', 3'- dideoxynucleoside, were as potent as 2 ', 3 '-dideoxyinosine (ddI, didanosine, Videx). Although the antiviral activities of 17 and 18 were equivalent, 18 was more cytotoxic. ...