We describe an efficient and scalable synthesis of 4-carbomethoxy-6, 6′-dimethyl-2, 2′- bipyridine starting from easily available substituted 2-halopyridines and based on the application of modified Negishi cross-coupling conditions. This compound is a versatile starting material for the synthesis of 4-functionalized 2, 2′-bipyridines bearing halide, alcohol, amine, and other functionalities, suitable for conjugation to biological material (2a ...
