Tetrahedron

6, 6′-Dimethyl-2, 2′-bipyridine-4-ester: A pivotal synthon for building tethered bipyridine ligands

F Havas, N Leygue, M Danel, B Mestre, C Galaup…

Index: Havas, Fabien; Leygue, Nadine; Danel, Mathieu; Mestre, Beatrice; Galaup, Chantal; Picard, Claude Tetrahedron, 2009 , vol. 65, # 36 p. 7673 - 7686

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Citation Number: 26

Abstract

We describe an efficient and scalable synthesis of 4-carbomethoxy-6, 6′-dimethyl-2, 2′- bipyridine starting from easily available substituted 2-halopyridines and based on the application of modified Negishi cross-coupling conditions. This compound is a versatile starting material for the synthesis of 4-functionalized 2, 2′-bipyridines bearing halide, alcohol, amine, and other functionalities, suitable for conjugation to biological material (2a ...