A new method for 5-(4-hydroxyphenyl) hydantoin synthesis

T Ohashi, S Takahashi, T Nagamachi…

文献索引：Ohashi; Takahashi; Nagamachi; et al. Agricultural and Biological Chemistry, 1981 , vol. 45, # 4 p. 831 - 838

全文：HTML全文

被引用次数: 34

摘要

5-(4-Hydroxyphenyl) hydantoin (p-HPH), an important intermediate in production of D-2-(4- hydroxyphenyI) glycine, was synthesized by employing new amidoalkylation reaction of phenol with glyoxylic acid and urea under acidic conditions, accompanied by formation of the isomer, ie. 5-(2-hydroxyphenyl) hydantoin (o-HPH). The ratio of p-HPH was found to be mainly influenced by the reaction method (the manner of charging raw materials) and ...