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举例 :可输入Filippa Pettersson 或者 Cancer Res. 75(6) , 1102-12, (2015) 或者10.1002/anie.201600521

α-(4-Tolyl) dopamine, derivatives and analogues; Synthesis and pharmacological screening

V Valenta, J Holubek, E Svátek, A Dlabač…

文献索引：Valenta; Holubek; Svatek; et al. Collection of Czechoslovak Chemical Communications, 1983 , vol. 48, # 5 p. 1447 - 1464

全文：HTML全文

被引用次数: 8

摘要

Abstract The ketone XIII, obtained by Friedel-Crafts reaction of toluene with homoveratroyl chloride, was converted by the Leuckart reaction to the formamido derivative IXb which was used as the starting product for the synthesis of amines IIIb-Vb. Reduction of the ketone XIII gave the alcohol XVI which was treated with hydrogen chloride and afforded the chloro compound XVII. Its substitution reactions with 1-methylpiperazine, 1-(2-hydroxyethyl) ...

N-(2-(3,4-dimethoxyphenyl)-1-(4-tolyl)ethyl)acetamide结构式

N-(2-(3,4-dimet...

~%

6,7-dimethoxy-1-methyl-3-(4-methylphenyl)-1,2,3,4-tetrahydroisoquinoline,hydrochloride结构式

6,7-dimethoxy-1...

2-(3,4-dimethoxyphenyl)-1-(4-methylphenyl)ethanamine,hydrochloride结构式

2-(3,4-dimethox...

~%

6,7-dimethoxy-1-methyl-3-(4-methylphenyl)-1,2,3,4-tetrahydroisoquinoline,hydrochloride结构式

6,7-dimethoxy-1...

6,7-dimethoxy-1-methyl-3-(4-tolyl)-3,4-dihydroisoquinoline结构式

6,7-dimethoxy-1...

~%

6,7-dimethoxy-1-methyl-3-(4-methylphenyl)-1,2,3,4-tetrahydroisoquinoline,hydrochloride结构式

6,7-dimethoxy-1...

2-(3,4-dimethoxyphenyl)-N,N-dimethyl-1-(4-methylphenyl)ethanamine,hydrochloride结构式

2-(3,4-dimethox...

~%

[2-benzoyloxy-4-[2-(dimethylamino)-2-(4-methylphenyl)ethyl]phenyl] benzoate,hydrochloride结构式

[2-benzoyloxy-4...

4-(2-(Dimethylamino)-2-(4-methylphenyl)ethyl)-1,2-benzenediol hydrobro mide结构式

4-(2-(Dimethyla...

苯甲酰氯结构式

~%

[2-benzoyloxy-4-[2-(dimethylamino)-2-(4-methylphenyl)ethyl]phenyl] benzoate,hydrochloride结构式

[2-benzoyloxy-4...

(3,4-二甲氧基苯基)乙酰氯结构式

(3,4-二甲氧基苯基)乙酰氯

~%

1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-3-(4-methylphenyl)-1,2,3,4-tetrahydroisoquinoline,hydrochloride结构式

1-[(3,4-dimetho...

2-(3,4-dimethoxyphenyl)-1-(4-methylphenyl)ethanamine,hydrochloride结构式

2-(3,4-dimethox...

~%

1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-3-(4-methylphenyl)-1,2,3,4-tetrahydroisoquinoline,hydrochloride结构式

1-[(3,4-dimetho...

N-(2-(3,4-dimethoxyphenyl)-1-(4-tolyl)ethyl)-3,4-dimethoxyphenylacetamide结构式

N-(2-(3,4-dimet...

~%

1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-3-(4-methylphenyl)-1,2,3,4-tetrahydroisoquinoline,hydrochloride结构式

1-[(3,4-dimetho...

N-(2-(3,4-dimethoxyphenyl)-1-(4-tolyl)ethyl)acetamide结构式

N-(2-(3,4-dimet...

~%

1-methyl-3-(4-methylphenyl)-1,2,3,4-tetrahydroisoquinoline-6,7-diol,hydrobromide结构式

1-methyl-3-(4-m...

2-(3,4-dimethoxyphenyl)-1-(4-methylphenyl)ethanamine,hydrochloride结构式

2-(3,4-dimethox...

~%

1-methyl-3-(4-methylphenyl)-1,2,3,4-tetrahydroisoquinoline-6,7-diol,hydrobromide结构式

1-methyl-3-(4-m...

6,7-dimethoxy-1-methyl-3-(4-methylphenyl)-1,2,3,4-tetrahydroisoquinoline,hydrochloride结构式

6,7-dimethoxy-1...

~%

1-methyl-3-(4-methylphenyl)-1,2,3,4-tetrahydroisoquinoline-6,7-diol,hydrobromide结构式

1-methyl-3-(4-m...

6,7-dimethoxy-1-methyl-3-(4-tolyl)-3,4-dihydroisoquinoline结构式

6,7-dimethoxy-1...

~%

1-methyl-3-(4-methylphenyl)-1,2,3,4-tetrahydroisoquinoline-6,7-diol,hydrobromide结构式

1-methyl-3-(4-m...

1-[2-(3,4-dimethoxyphenyl)-1-(4-methylphenyl)ethyl]-4-methylpiperazine,dihydrochloride结构式

1-[2-(3,4-dimet...

~72%

4-(2-(4-Methylphenyl)-2-(4-methyl-1-piperazinyl)ethyl)-1,2-benzenediol dihydrobromide hydrate结构式

4-(2-(4-Methylp...

2-(3,4-dimethoxyphenyl)-N,N-dimethyl-1-(4-methylphenyl)ethanamine,hydrochloride结构式

2-(3,4-dimethox...

~68%

4-(2-(Dimethylamino)-2-(4-methylphenyl)ethyl)-1,2-benzenediol hydrobro mide结构式

4-(2-(Dimethyla...

6,7-dimethoxy-3-(4-methylphenyl)-1,2,3,4-tetrahydroisoquinoline,hydrochloride结构式

6,7-dimethoxy-3...

~95%

6,7-Dihydroxy-3-(4-tolyl)-1,2,3,4-tetrahydroisoquinoline hydrobromide结构式

6,7-Dihydroxy-3...

(3,4-二甲氧基苯基)乙酰氯结构式

(3,4-二甲氧基苯基)乙酰氯

~%

6,7-Dihydroxy-3-(4-tolyl)-1,2,3,4-tetrahydroisoquinoline hydrobromide结构式

6,7-Dihydroxy-3...

N-[2-(3,4-dimethoxyphenyl)-1-(4-methylphenyl)ethyl]formamide结构式

N-[2-(3,4-dimet...

~%

6,7-Dihydroxy-3-(4-tolyl)-1,2,3,4-tetrahydroisoquinoline hydrobromide结构式

6,7-Dihydroxy-3...

甲苯结构式

~%

6,7-Dihydroxy-3-(4-tolyl)-1,2,3,4-tetrahydroisoquinoline hydrobromide结构式

6,7-Dihydroxy-3...

未登录结构式

~%

6,7-Dihydroxy-3-(4-tolyl)-1,2,3,4-tetrahydroisoquinoline hydrobromide结构式

6,7-Dihydroxy-3...

2-(3,4-dimethoxyphenyl)-N-methyl-1-(4-methylphenyl)ethanamine,hydrochloride结构式

2-(3,4-dimethox...

~99%

4-[2-(methylamino)-2-(4-methylphenyl)ethyl]benzene-1,2-diol,hydrobromide结构式

4-[2-(methylami...

(3,4-二甲氧基苯基)乙酰氯结构式

(3,4-二甲氧基苯基)乙酰氯

~%

1,2-dimethoxy-4-[2-(4-methylphenyl)ethenyl]benzene结构式

1,2-dimethoxy-4...

甲苯结构式

~%

1,2-dimethoxy-4-[2-(4-methylphenyl)ethenyl]benzene结构式

1,2-dimethoxy-4...

1-(2-(3,4-dimethoxyphenyl)-1-(4-tolyl)ethyl)-4-(2-hydroxyethyl)piperazine结构式

1-(2-(3,4-dimet...

~74%

4-[2-[4-(2-hydroxyethyl)piperazin-1-yl]-2-(4-methylphenyl)ethyl]benzene-1,2-diol,dihydrobromide结构式

4-[2-[4-(2-hydr...

N-羟乙基哌嗪结构式

N-羟乙基哌嗪

~%

4-[2-[4-(2-hydroxyethyl)piperazin-1-yl]-2-(4-methylphenyl)ethyl]benzene-1,2-diol,dihydrobromide结构式

4-[2-[4-(2-hydr...

(3,4-二甲氧基苯基)乙酰氯结构式

(3,4-二甲氧基苯基)乙酰氯

~%

4-[2-[4-(2-hydroxyethyl)piperazin-1-yl]-2-(4-methylphenyl)ethyl]benzene-1,2-diol,dihydrobromide结构式

4-[2-[4-(2-hydr...

2-(3,4-dimethoxyphenyl)-1-(4-tolyl)ethyl chloride结构式

2-(3,4-dimethox...

~%

4-[2-[4-(2-hydroxyethyl)piperazin-1-yl]-2-(4-methylphenyl)ethyl]benzene-1,2-diol,dihydrobromide结构式

4-[2-[4-(2-hydr...

甲苯结构式

~%

4-[2-[4-(2-hydroxyethyl)piperazin-1-yl]-2-(4-methylphenyl)ethyl]benzene-1,2-diol,dihydrobromide结构式

4-[2-[4-(2-hydr...

(3,4-二甲氧基苯基)乙酰氯结构式

(3,4-二甲氧基苯基)乙酰氯

~%

6,7-dimethoxy-3-(4-methylphenyl)-1,2,3,4-tetrahydroisoquinoline,hydrochloride结构式

6,7-dimethoxy-3...

N-[2-(3,4-dimethoxyphenyl)-1-(4-methylphenyl)ethyl]formamide结构式

N-[2-(3,4-dimet...

~%

6,7-dimethoxy-3-(4-methylphenyl)-1,2,3,4-tetrahydroisoquinoline,hydrochloride结构式

6,7-dimethoxy-3...

甲苯结构式

~%

6,7-dimethoxy-3-(4-methylphenyl)-1,2,3,4-tetrahydroisoquinoline,hydrochloride结构式

6,7-dimethoxy-3...

未登录结构式

~%

6,7-dimethoxy-3-(4-methylphenyl)-1,2,3,4-tetrahydroisoquinoline,hydrochloride结构式

6,7-dimethoxy-3...