Agents for the treatment of brain edema. 2.[(2, 3, 9, 9a-Tetrahydro-3-oxo-9a-substituted-1H-fluoren-7-yl) oxy] alkanoic acids and some of their analogs

…, AM Pietruszkiewicz, C Ziegler, Y Sakurai…

文献索引：Cragoe; Woltersdorf; Gould; Pietruszkiewicz; Ziegler; Sakurai; Stokker; Anderson; Bourke; Kimelberg Journal of Medicinal Chemistry, 1986 , vol. 29, # 5 p. 825 - 841

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被引用次数: 60

摘要

Our initial paper discussed brain edema resulting from traumatic head injury and the need for specific and effective agents to treat the disorder and disclosed a novel approach for the discovery of a drug of this kind. The current study describes the synthesis of a series of [(2, 3, 9, 9a-tetrahydro-3-oxo-9a-substituted-1H-fluoren-7-yl) oxy] alkanoic acids and their analogues. These compounds were evaluated in an in vitro cerebrocortical tissue slice ...