Organic letters

Cyanocuprates convert carboxylic acids directly into ketones

DT Genna, GH Posner

文献索引：Genna, Douglas T.; Posner, Gary H. Organic Letters, 2011 , vol. 13, # 19 p. 5358 - 5361

被引用次数: 25

摘要

Carboxylic acids were converted directly in 56–99% yields into methyl, n-butyl, and isopropyl ketones using excess cyanocuprates R2CuLi· LiCN. A substrate with a stereocenter α to the carboxylic acid was converted into ketones with very little loss of enantiomeric purity. A variety of functional groups were tolerated including aryl bromides. This direct transformation of a carboxylic acid into ketone with minimal tertiary alcohol ...

~76%

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~73%

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~57%

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~91%

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~78%

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~80%

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~79%

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~90%

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~91%

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~89%

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~92%

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~74%

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~93%

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~91%

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~86%

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~95%

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