Synthesis and structure activity relationships of potent new angiotensin converting enzyme inhibitors containing saturated bicyclic amino acids

CJ Blankley, JS Kaltenbronn, DE DeJohn…

文献索引：Blankley; Kaltenbronn; DeJohn; Werner; Bennett; Bobowski; Krolls; Johnson; Pearlman; Hoefle Journal of Medicinal Chemistry, 1987 , vol. 30, # 6 p. 992 - 998

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被引用次数: 54

摘要

The synthesis of a series of novel, potent angiotensin converting enzyme (ACE) inhibitors containing saturated bicyclic amino acids in place of proline is described. Octahydroindole-2- carboxylic acid, octahydroisoindole-1-carboxylic acid, and octahydro-3-oxoisoindole-1- carboxylic acid can replace proline in both sulfhydryl and non-sulfhydryl ACE inhibitors to give compounds equipotent to captopril and enalapril both in vitro and in vivo. Structure- ...