Chirality

Practical access to the proline analogs (S, S, S)??and (R, R, R)??2??methyloctahydroindole??2??carboxylic acids by HPLC enantioseparation

…, MJ Pueyo, MI Calaza, AI Jiménez, C Cativiela

文献索引：Sayago, Francisco J.; Pueyo, Maria J.; Calaza, M. Isabel; Jimenez, Ana I.; Cativiela, Carlos Chirality, 2011 , vol. 23, # 7 p. 507 - 513

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被引用次数: 10

摘要

Abstract An efficient methodology for the preparation of the α-tetrasubstituted proline analog (S, S, S)-2-methyloctahydroindole-2-carboxylic acid,(S, S, S)-(αMe) Oic, and its enantiomer,(R, R, R)-(αMe) Oic, has been developed. Starting from easily available substrates and through simple transformations, a racemic precursor has been synthesized in excellent yield and further subjected to HPLC resolution using a cellulose-derived chiral ...