Synthesis of analogs of (1, 4)-3-and 5-imino oxazepane, thiazepane, and diazepane as inhibitors of nitric oxide synthases

…, P Chen, WK Hagmann, M MacCoss, JL Humes…

文献索引：Shankaran; Donnelly, Karla L.; Shah, Shrenik K.; Caldwell, Charles G.; Chen, Ping; Hagmann, William K.; MacCoss, Malcolm; Humes, John L.; Pacholok, Stephen G.; Kelly, Theresa M.; Grant, Stephan K.; Wong, Kenny K. Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 23 p. 5907 - 5911

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被引用次数: 16

摘要

Download PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... A series of 3- and 5-imino analogs from oxazepane, thiazepane, and diazepane was prepared and evaluated as inhibitors of human nitric oxide synthesis (NOS). The most potent iNOS inhibitor was the thiazepane analog 25 (IC 50 = 0.19 μM). ... The preparation and SAR of a series of iNOS inhibitors ...