Synthesis of DNA-directed pyrrolidinyl and piperidinyl confined alkylating chloroalkylaminoanthraquinones: potential for development of tumor-selective N-oxides

K Pors, SD Shnyder, PH Teesdale-Spittle…

文献索引：Pors, Klaus; Shnyder, Steven D.; Teesdale-Spittle, Paul H.; Hartley, John A.; Zloh, Mire; Searcey, Mark; Patterson, Laurence H. Journal of Medicinal Chemistry, 2006 , vol. 49, # 24 p. 7013 - 7023

全文：HTML全文

被引用次数: 30

摘要

A novel series of 1, 4-disubstituted chloroethylaminoanthraquinones, containing alkylating chloroethylamino functionalities as part of a rigid piperidinyl or pyrrolidinyl ring-system, have been prepared. The target compounds were prepared by ipso-displacement of halides of various anthraquinone chromophores by either hydroxylated or chlorinated piperidinyl-or pyrrolidinyl-alkylamino side chains. The chloroethylaminoanthraquinones were shown to ...