CH~ O''OCH~ CH30 OCH3 lie 3i e Method A: The enolate of 1 was generated with 2.2 equiv of NaH in THF (0.2 M) at 0 to 25" C. Method B: The enolate of 1 was generated with 1.2 equiv of LDA in THF (0.2 M) at-78 to-5" C. Method C: The enolate of 1 was generated with 1.2 equiv of LDA in THF (0.2 M) at-78 to-5" C, and closure to the a-pyrone was effected with acetic anhydride treatment at 100 to 130" C. Method D: equiv of NaH in THF (0.2 M) at 0 to ...
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