Department of Chemistry, Georgia State University, Atlanta, Georgia 30303 Receiued May 10, 1991 4, bDimethyl-and 4, 5, 6-trimethyl-substituted pyrimidines are brominated at C5-Me with NBS in CCl, and at C4 (6)-Me with bromine in acetic acid to give the corresponding bromomethyl derivatives in a high yield. The remaining methyl group (s) can also be brominated with high regioselectivity. The 2-methylthio substituent is not oxidized under ...
