Highly regioselective bromination reactions of polymethylpyrimidines

L Strekowski, RL Wydra, L Janda…

Index: Strekowski, Lucjan; Wydra, Roman L.; Janda, Lubomir; Harden, Donald B. Journal of Organic Chemistry, 1991 , vol. 56, # 19 p. 5610 - 5614

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Citation Number: 21

Abstract

Department of Chemistry, Georgia State University, Atlanta, Georgia 30303 Receiued May 10, 1991 4, bDimethyl-and 4, 5, 6-trimethyl-substituted pyrimidines are brominated at C5-Me with NBS in CCl, and at C4 (6)-Me with bromine in acetic acid to give the corresponding bromomethyl derivatives in a high yield. The remaining methyl group (s) can also be brominated with high regioselectivity. The 2-methylthio substituent is not oxidized under ...