Quinoline and its derivatives are among the most important synthetic or natural heterocycles with interesting biological activities showing anti-malarial, anti-inflammatory, anti-bacterial, and anti-asthmatic properties. 1 As a result, the quinoline scaffolds have spurred the development of a great deal of synthetic methodologies. Among those variations, the Friedländer reaction 2 is one of the simplest, straightforward, and most widely used approaches. 3 This ...
