Abstract Thirteen pyrrolidine-based iminosugar derivatives have been synthesized and evaluated for inhibition of α-glucosidase from rat intestine. The compounds studied were the non-hydroxy, mono-hydroxy and dihydroxypyrrolidines. All the compounds were N- benzylated apart from one. Four of the compounds had a carbonyl group in the 2, 5-position of the pyrrolidine ring. The most promising iminosugar was the trans-3, 4- ...
