Chemistry and Pharmacology of Some Esters Derived from Basic Alcohols

FP Doyle, MD Mehta, R Ward…

文献索引：Doyle,F.P. et al. Journal of Medicinal Chemistry, 1965 , vol. 8, p. 571 - 576

被引用次数: 7

摘要

The preparation of a number of a-alkoxy-apdiphenylacetates derived from open-chain basic alcohols is described. Some of these compounds possess antitussive activity comparable to that of codeine phosphate and of the same order as that of their analogs which contain pyrrolidine or piperidine rings. 2-Diethylamino-l-(01-methoxy-a, a-dipheny1acetoxy) propane rearranged on heating to l-diethylamino-2-(01-methoxy-01,~-diphenyl-acetoxy) ...