Chemistry and Pharmacology of Some Esters Derived from Basic Alcohols

FP Doyle, MD Mehta, R Ward…

Index: Doyle,F.P. et al. Journal of Medicinal Chemistry, 1965 , vol. 8, p. 571 - 576

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Citation Number: 7

Abstract

The preparation of a number of a-alkoxy-apdiphenylacetates derived from open-chain basic alcohols is described. Some of these compounds possess antitussive activity comparable to that of codeine phosphate and of the same order as that of their analogs which contain pyrrolidine or piperidine rings. 2-Diethylamino-l-(01-methoxy-a, a-dipheny1acetoxy) propane rearranged on heating to l-diethylamino-2-(01-methoxy-01,~-diphenyl-acetoxy) ...