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Novel deoxy-selenylconduritols: chemoenzymatic synthesis and biological evaluation

…, A Bertucci, H Stefani, A Vazquez, D Gonzalez

文献索引:Bellomo, Ana; Bertucci, Ana; Stefani, Helio; Vazquez, Alvaro; Gonzalez, David Tetrahedron Asymmetry, 2009 , vol. 20, # 23 p. 2673 - 2676

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被引用次数: 8

摘要

The first synthesis of two selenyldeoxycyclitols (4-bromo-2-phenylselenyl conduritol F and 6- phenylselenylconduritol F) is reported via a chemoenzymatic enantioselective route. The key step of the synthesis is the selenolysis of a vinyl epoxide. The new compounds were evaluated for their capacity to inhibit the growth of different microorganisms using a modification of the agar diffusion technique with thin layer chromatography plates as ...