A novel and highly efficient synthetic route to unsymmetrical organoselenides using cesium bases

RJ Cohen, DL Fox, RN Salvatore

文献索引：Cohen, Richard J.; Fox, Daniel L.; Salvatore, Ralph Nicholas Journal of Organic Chemistry, 2004 , vol. 69, # 12 p. 4265 - 4268

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被引用次数: 69

摘要

A new and convenient one-pot method for the preparation of unsymmetrical selenides has been developed. In the presence of cesium hydroxide, molecular sieves, and DMF, benzeneselenol undergoes direct alkylation with various alkyl halides for the synthesis of alkyl phenyl selenides in moderate to excellent yields. Another method to prepare unsymmetrical organoselenides was also completed by coupling terminal alkynes with ...