Journal of medicinal chemistry

Synthesis and pharmacological evaluation of some 6-substituted 7-methyl-1, 4-dioxa-7-azaspiro [4.5] decanes as potential dopamine agonists

AN Brubaker, M Colley Jr

文献索引：Brubaker; Colley Jr. Journal of Medicinal Chemistry, 1986 , vol. 29, # 8 p. 1528 - 1531

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被引用次数: 9

摘要

Three 7-methyl-1, 4-dioxa-7-azaspiro [4.5] decanea that contained either the benzyl, 3- indolylmethyl, or Cindolylmethyl group at the 6-position were synthesized via alkylation of the pyrrolidine enamine of the key intermediate, ethyl 3-oxopiperidine-l-carboxylate. The