Tetrahedron letters

N-Alkylation of diethyl acetamidomalonate: synthesis of constrained amino acid derivatives by ring-closing metathesis

S Kotha, K Singh

文献索引：Kotha, Sambasivarao; Singh, Kuldeep Tetrahedron Letters, 2004 , vol. 45, # 52 p. 9607 - 9610

全文：HTML全文

被引用次数: 21

摘要

An efficient method for N-alkylation of diethyl acetamidomalonate (DEAM) is reported. C- Alkenylation was achieved by treating the N-alkenylated DEAM with various electrophiles in the presence of Cs2CO3. RCM reactions of C-and N-alkenylated products gave cyclic amino acid derivatives in good yields.