Tetrahedron letters

N-Alkylation of diethyl acetamidomalonate: synthesis of constrained amino acid derivatives by ring-closing metathesis

S Kotha, K Singh

Index: Kotha, Sambasivarao; Singh, Kuldeep Tetrahedron Letters, 2004 , vol. 45, # 52 p. 9607 - 9610

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Citation Number: 21

Abstract

An efficient method for N-alkylation of diethyl acetamidomalonate (DEAM) is reported. C- Alkenylation was achieved by treating the N-alkenylated DEAM with various electrophiles in the presence of Cs2CO3. RCM reactions of C-and N-alkenylated products gave cyclic amino acid derivatives in good yields.