Tetrahedron letters

Total synthesis of antibiotic karnamicin B 1

…, K Watanabe, K Ono, M Yamaura, J Yoshimura

文献索引：Umemura, Kazuyuki; Watanabe, Koichi; Ono, Kazumasa; Yamaura, Masanori; Yoshimura, Juji Tetrahedron Letters, 1997 , vol. 38, # 27 p. 4811 - 4814

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被引用次数: 10

摘要

The novel antifungal karnamicin B1 (1), 5-hydroxy-3, 4-dimethoxy-2-{2-(4-oxopentyl)-4- thiazolyl} pyridine-6-carboxamide was first synthesized via the formation of partially methylated trihydroxy pyridine by ring-transformation from the corresponding furan derivative and subsequent regioselective introduction of 2, 6-substituents using Meisenheimer-type reaction.