The discovery of the strong anticancer activity of some quinazoline derivatives 1., , , and has caused increased interest in the synthesis of quinazolines. 2., , , , , , , and A search through the review literature concerning quinazolines shows that only very little is known about synthesis of the system via the formation of the 1,8a bond. 3 For example, in Brown's monograph on quinazolines 4 this route was called 'unappealing' and only half a page was dedicated to it. The reason ...
