Tetrahedron letters

Transformation of 5, 5-diaryl-4, 5-dihydro-1, 2, 4-oxadiazoles to 4-arylquinazolines

W Szczepankiewicz, P Wagner, M Danicki, J Suwiński

Index: Szczepankiewicz, Wojciech; Wagner, Pawel; Danicki, Miroslaw; Suwinski, Jerzy Tetrahedron Letters, 2003 , vol. 44, # 10 p. 2015 - 2017

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Citation Number: 11

Abstract

The discovery of the strong anticancer activity of some quinazoline derivatives 1., , , and has caused increased interest in the synthesis of quinazolines. 2., , , , , , , and A search through the review literature concerning quinazolines shows that only very little is known about synthesis of the system via the formation of the 1,8a bond. 3 For example, in Brown's monograph on quinazolines 4 this route was called 'unappealing' and only half a page was dedicated to it. The reason ...