Synthesis of 2-alkoxy 1, 4-naphthoquinone derivatives as antiplatelet, antiinflammatory, and antiallergic agents.

JC Lien, LJ Huang, CM Teng, JP Wang…

文献索引：Lien, Jin-Cherng; Huang, Li-Jiau; Teng, Che-Ming; Wang, Jih-Pyang; Kuo, Sheng-Chu Chemical and Pharmaceutical Bulletin, 2002 , vol. 50, # 5 p. 672 - 674

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被引用次数: 41

摘要

In our continuing search for novel antiplatelet, antiallergic, and antiinflammatory agents, 2- alkoxy derivatives of 1, 4-naphthoquinone were prepared. Some of these compounds showed significant antiplatelet, antiallergic, and antiinflammatory activities. Among them, 2- propoxy-1, 4-naphthoquinone and 2-butoxy-1, 4-naphthoquinone exhibited potent inhibitory effect on neutrophil superoxide anion formation. These two compounds are worthy of ...