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Ortho-lithiated tertiary benzamides. Chain extension via o-toluamide anion and general synthesis of isocoumarins including hydrangenol and phyllodulcin

…, S Furukawa, RJ Billedeau, V Snieckus

文献索引:Watanabe, Mitsuaki; Sahara, Masanori; Kubo, Masaki; Furukawa, Sunao; Billedeau, R. J.; Snieckus, V. Journal of Organic Chemistry, 1984 , vol. 49, # 5 p. 742 - 747

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被引用次数: 62

摘要

2a thiophene-3-CHO 4f 30 77-78 (Et, O) a All new compounds show analytical data (C, H, N) in agreement (i0. 3%) with expected molecular formula. Yields correspond to recrystallized products. mp not given by Creger, ref 4d. var. otakusa Maxim) and phyllodulcin (1Oc)(H. serrata Seringe var. thunbergii Sugimoto). loJ'The discovery that phyllodulcin is 400 times as sweet as sucro~ e~~,~~ as well as the demonstration of antifungal and other ...

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