Partly reduced biphenyls as central nervous system agents. 1. 4-Arylcyclohex-3-enylamines

D Lednicer, DE Emmert, R Lahti…

文献索引：Lednicer; Emmert; Lahti; Rudzik Journal of medicinal chemistry, 1972 , vol. 15, # 12 p. 1235 - 1238

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被引用次数: 6

摘要

A series of 4-arylcyclohex-3-en-l-ones was prepared in several steps from 4- hydroxycyclohexanone and the appropriate Grignard reagents. The ketones were elaborated to the corresponding f-arylcyclohex-3-en-1-ylamines. These were converted to several derivatives, including piperidines and 4-fluoro-Cbutyrophenones. The products were tested in a series of assays for CNS activity; the last compounds were particularly active ...