Role of the (acyloxy) methyl moiety in eliciting the adrenergic. beta.-blocking activity of 3-(acyloxy) propanolamines

B Macchia, A Balsamo, A Lapucci…

文献索引：Macchia, B.; Balsamo, A.; Lapucci, A.; Macchia, F.; Martinelli, A.; et al. Journal of Medicinal Chemistry, 1987 , vol. 30, # 4 p. 616 - 622

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被引用次数: 18

摘要

Totally aliphatic compounds of class C (6-10, Rz= alkyl, class C') were therefore synthesized in order to verify whether the C (3)-0 (2)-C (4)-0 (3) moiety could elicit a@-blocking activity in this class of even when not linked to an aromatic group. In the course of the work three new compounds of class C (11-13), containing a thienyl group, were also prepared. The EMP of model compounds of class C and C'drugs was calculated in order to study the electrostatic ...