Tetrahedron

A facile and rapid one-step synthesis of 8-substituted xanthine derivatives via tandem ring closure at room temperature

P Bandyopadhyay, SK Agrawal, M Sathe, P Sharma…

文献索引：Bandyopadhyay, Prabal; Agrawal, Sumit K.; Sathe, Manisha; Sharma, Pratibha; Kaushik Tetrahedron, 2012 , vol. 68, # 20 p. 3822 - 3827

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被引用次数: 13

摘要

N-Bromo succinimide (NBS) was found to be an efficient and regioselective reagent in combination with AIBN for an unprecedented, facile and rapid one-step synthesis of 8- substituted xanthine derivatives at room temperature. The inexpensive, nontoxic and readily available NBS efficiently promoted the condensation of several aryl/cycloaryl/heteroaryl aldehydes with 5, 6-diamino-1, 3-dimethyluracils in presence of catalytic amount of AIBN ...