The Journal of Organic Chemistry

Synthesis of substituted cyclooctanols by a samarium (II) iodide promoted 8-endo radical cyclization process

GA Molander, JA McKie

文献索引：Molander, Gary A.; McKie, Jeffrey A. Journal of Organic Chemistry, 1994 , vol. 59, # 11 p. 3186 - 3192

全文：HTML全文

被引用次数: 103

摘要

Samarium (I1) iodide (SmIz) has been employed to promote an efficient 8-endo radical cyclization reaction of a variety of substituted olefinic ketones. Various substituted monocyclic, fused bicyclic, and bridged bicyclic cyclooctanols have been synthesized in fair to excellent yield via this protocol. In addition to delineating the synthetic potential of this reaction, experiments have been conducted to determine the source of reduced, ...