Gold??Catalyzed Cyclization of Nonterminal Propargylic Amides to Substituted Alkylideneoxazolines and??oxazines

…, AM Schuster, M Schmuck, F Rominger

文献索引：Hashmi, A. Stephen K.; Schuster, Andreas M.; Schmuck, Martin; Rominger, Frank European Journal of Organic Chemistry, 2011 , # 24 p. 4595 - 4602

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被引用次数: 22

摘要

Abstract The substrate scope of the gold-catalyzed cyclization of nonterminal propargylic amides to oxazolines and oxazines was investigated. Sixteen alkyl-substituted and 35 aryl- substited substrates were prepared by a very variable route from trimethylsilyl-(TMS-) protected, nonterminal propargylamines. Steric and electronic influences of the substituents on product selectivity were studied. A chloromethyl substituent on the alkyne shows an ...