Synthesis and Evaluation of a Novel Synthetic Phosphocholine Lipid??AZT Conjugate That Double??Targets Wild??Type and Drug Resistant Variants of HIV

LS Kucera, SL Morris??Natschke, KS Ishaq…

文献索引：Kucera, Louis S.; Morris-Natschke, Susan L.; Ishaq, Khalid S.; Hes, Jan; Iyer, Nathan; Furman, Phillip A.; Fleming, Ronald A. Nucleosides, Nucleotides and Nucleic Acids, 2004 , vol. 23, # 1-2 p. 385 - 399

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被引用次数: 9

摘要

INK??20, a synthetic phosphocholine lipid??AZT conjugate, was evaluated for antiviral activity against wild??type HIV??1, a matched pair of pre??AZT and post??AZT and multi??drug resistant clinical isolates. In addition, it was tested for activity against viruses resistant to nucleoside (AZT, 3TC) and nonnucleoside (nevirapine) reverse transcriptase and protease (saquinavir) inhibitors using the syncytial plaque reduction assay for infectious virus multiplication. The ...