Organic letters

Highly Efficient Preparation of Selectively Isotope Cluster-Labeled Long Chain Fatty Acids via Two Consecutive Csp3–Csp3 Cross-Coupling Reactions

S Lethu, S Matsuoka, M Murata

文献索引：Lethu, Sebastien; Matsuoka, Shigeru; Murata, Michio Organic Letters, 2014 , vol. 16, # 3 p. 844 - 847

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被引用次数: 6

摘要

An efficient synthesis involving two copper-catalyzed alkyl–alkyl coupling reactions has been designed to easily access doubly isotope-labeled fatty acids. Such NMR-and IR-active compounds were obtained in excellent overall yields and will be further used for determining the conformation of an alkyl chain of lipidic biomolecules upon interaction with proteins.