Chemistry–A European Journal

Photocaging strategy for functionalisation of oligonucleotides and its applications for oligonucleotide labelling and cyclisation

M Su, J Wang, XJ Tang

文献索引：Su, Meng; Wang, Jie; Tang, Xinjing Chemistry - A European Journal, 2012 , vol. 18, # 31 p. 9628 - 9637

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被引用次数: 13

摘要

Abstract We have used a photocaging strategy to develop novel phosphoramidites and expand the repertoire of protecting groups for modification of oligonucleotides by solid- phase synthesis. We synthesised five photolabile phosphoramidites and four new photolabile controlled pore glasses (CPGs). By using these photolabile phosphoramidites and CPGs, modified oligodeoxynucleotides (ODNs) with phosphate, amine, acid, thiol and ...