Liebigs Annalen der Chemie

The synthesis of 1??aminoalkylphosphonic acids. A revised mechanism of the reaction of phosphorus trichloride, amides and aldehydes or ketones in acetic acid ( …

M Soroka

文献索引：Soroka, Miroslaw Liebigs Annalen der Chemie, 1990 , # 4 p. 331 - 334

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被引用次数: 33

摘要

Abstract The mechanism of the amidoalkylation of trivalent phosphorus compounds in acetic acid has been reinvestigated. Evidence is presented that 1-(acylamino) alkyl acetates 5 and not N, N′-alkylidenebisamides 2 are the intermediates in this reaction. Supporting literature analogies are discussed. This paper also describes a convenient procedure for the preparation of crude (acylamino) alkyl alkanoates 5, which are excellent amidoalkylating ...