3-Amino-. beta.-carboline derivatives and the benzodiazepine receptor. Synthesis of a selective antagonist of the sedative action of diazepam

…, L Prado de Carvalho, A Valin, P Venault…

文献索引：Dodd; Ouannes; Prado de Carvalho; Valin; Venault; Chapouthier; Rossier; Potier Journal of Medicinal Chemistry, 1985 , vol. 28, # 6 p. 824 - 828

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被引用次数: 49

摘要

5 R'= CHZOH R2; R3= R4= R5; H carboxyl group and the nitrogen of the pyridino ring has also been suggested. 18 It thus seemed interesting to us to study the binding characteristics of 3-amino-@-carboline (8) and its derivatives. The amino group contrary to the carbonyl group would serve to increase the electron density on the aromatic heterocycle, and furthermore, these electron-donating properties of the amine could be modulated by ...