3-Benzylamino-β-carboline derivatives induce apoptosis through G 2/M arrest in human carcinoma cells HeLa S-3

…, E Nishi, M Kurosawa, N Sakai, T Konakahara

文献索引：Ikeda, Reiko; Iwaki, Toshie; Iida, Tomoko; Okabayashi, Takasumi; Nishi, Eishiro; Kurosawa, Masaki; Sakai, Norio; Konakahara, Takeo European Journal of Medicinal Chemistry, 2011 , vol. 46, # 2 p. 636 - 646

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被引用次数: 34

摘要

β-Carboline derivatives are known as the lead compounds for anti-tumor agents. To examine an optimal structure for anti-tumor activity, we synthesized a variety of β-carboline derivatives, possessing a variety of substituents on the nitrogen atom of the amino group of 3- amino-β-carboline, and evaluated their anti-tumor activity for HeLa S-3 cell line. 3-(4, 5- Dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay showed that an ...