. beta.-Carbolines: synthesis and neurochemical and pharmacological actions on brain benzodiazepine receptors

M Cain, RW Weber, F Guzman, JM Cook…

文献索引：Cain; Weber; Guzman; Cook; Barker; Rice; Crawley; Paul; Skolnick Journal of Medicinal Chemistry, 1982 , vol. 25, # 9 p. 1081 - 1091

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被引用次数: 182

摘要

4, X= H; R= H 5, X= H; R= CH, 9, X= OH; R= CH, proposed~-carboline-3-carboxylic acid ethyl ester (0-CCE) as the endogenous factor, subsequent studies5s6 have shown that this compound is probably formed during the isolation and extraction procedure. Nonetheless, the demonstration that certain P-carbolines potently inhibit [3H] diazepam binding with a high affinity suggests this group of compounds may be useful both as tools for studying ...