Tetrahedron

2′-Deoxy-2′-alkoxylaminouridines: Novel 2′-substituted uridines prepared by intramolecular nucleophilic ring opening of 2, 2′-O-anhydrouridines

DP Sebesta, SS O'Rourke, RL Martinez, WA Pieken…

文献索引：Sebesta, David P.; O'Rourke, Sarah S.; Martinez, Rogelio L.; Pieken, Wolfgang A.; McGee, Danny P. C. Tetrahedron, 1996 , vol. 52, # 46 p. 14385 - 14402

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被引用次数: 22

摘要

Natural and unnatural modified nucleosides and nucleotides play important roles in biology, medicine, and as biomedical research tools. Reported herein is an application of synthetic methodology developed for the stereo-and regiospecific introduction of structural modifications at the 2′-position of uridine nucleosides. A novel class of modified nucleosides, 2′-alkoxylamino-2′-deoxy uridines, are prepared by intramolecular ...