Novel photoacid generators for photodirected oligonucleotide synthesis

PJ Serafinowski, PB Garland

文献索引：Serafinowski, Pawel J.; Garland, Peter B. Journal of the American Chemical Society, 2003 , vol. 125, # 4 p. 962 - 965

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被引用次数: 32

摘要

Photodirected oligonucleotide synthesis uses either direct or indirect light-dependent 5'- deprotection. Both have been reported to give lower stepwise synthetic yields than conventional methods. The deficiency appears to be due to incomplete deprotection at the oligonucleotide 5'-position and, additionally in the case where photodirection is indirect and uses photogenerated photoacid to effect 5'-detritylation, the depurinating effects of strong ...