Docking studies, synthesis, characterization of some novel oxazine substituted 9-anilinoacridine derivatives and evaluation for their antioxidant and anticancer …

R Kalirajan, V Kulshrestha, S Sankar, S Jubie

文献索引：Kalirajan; Kulshrestha, Vivek; Sankar; Jubie European Journal of Medicinal Chemistry, 2012 , vol. 56, p. 217 - 224

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被引用次数: 10

摘要

A series of 9-anilinoacridines substituted with oxazine derivatives were synthesized to evaluate their antioxidant and anticancer activity against Daltons Lymphoma Ascites (DLA) cell growth by in vitro method. It was revealed that these conjugates exhibited significant antioxidant and anticancer activity (inhibition of DLA cell proliferation). Among these agents, compounds 5a, 5h, 5i, 5j were the most cytotoxic with CTC50 value of 140–250 μg/mL. ...