Docking studies, synthesis, characterization of some novel oxazine substituted 9-anilinoacridine derivatives and evaluation for their antioxidant and anticancer …

R Kalirajan, V Kulshrestha, S Sankar, S Jubie

Index: Kalirajan; Kulshrestha, Vivek; Sankar; Jubie European Journal of Medicinal Chemistry, 2012 , vol. 56, p. 217 - 224

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Citation Number: 10

Abstract

A series of 9-anilinoacridines substituted with oxazine derivatives were synthesized to evaluate their antioxidant and anticancer activity against Daltons Lymphoma Ascites (DLA) cell growth by in vitro method. It was revealed that these conjugates exhibited significant antioxidant and anticancer activity (inhibition of DLA cell proliferation). Among these agents, compounds 5a, 5h, 5i, 5j were the most cytotoxic with CTC50 value of 140–250 μg/mL. ...