Journal of the Chinese Chemical Society

Heterocycles Derived from 5??(2??Aminothiazol??4??yl)??8??hydroxyquinoline: Synthesis and Antimicrobial Activity

SA Abdel??Mohsen

文献索引：Abdel-Mohsen, Shawkat A. Journal of the Chinese Chemical Society, 2003 , vol. 50, # 5 p. 1085 - 1092

全文：HTML全文

被引用次数: 15

摘要

Abstract 5-(2-Aminothiazol-4-yl)-8-hydroxyquinoline 2 has been synthesized by treating thiourea with 5-chloroacetyl-8-hydroxyquinoline 1. The amine 2 was treated with aromatic aldehydes to furnish schiff bases 6a-c which on treatment with phenyl isothiocyanate gave the corresponding thiazolo-s-triazines 7a-c. Reaction of 2 with phenyl isothiocyanate gave the corresponding aminocarbothiamide derivative 8 which on reaction with malonic acid ...